Liquids
We develop and manufacture liquid products by focusing on stable performance and reliable dose delivery.
Manufacturing-ready decisions
Liquids that scale consistently
For non‑sterile liquid drug products, pharmaceutical companies look for stable performance and dependable dose delivery across real‑world use conditions. Groupe PARIMA supports oral, topical, nasal, sublingual, and otic liquids by aligning formulation design, packaging, or device selection, and GMP execution, so programs scale smoothly and stay consistent.
Robust formula over shelf life
We connect formulation, in‑house analytics, and manufacturing to meet liquid product requirements for stability and solubility.
Proven stability expertise
We build formulations for consistent performance, including solutions, emulsions, and oil‑based formats.
MICROBIOLOGICAL CONTROL
We design preservative strategies supporting non‑sterile liquids across routes of administration.
PACKAGING AND DEVICE FIT
Align packaging components with formulation to support consistent dose delivery and user experience.
Reliable performance outcomes
We develop non-sterile liquid drug products, supported by fit-for-purpose testing to ensure consistent performance from development through scale-up.
DEFINE THE TARGET PRESENTATION
Translate the target product profile into clear requirements for route of administration, dosing approach, and user experience, then set the CQAs.
DESIGN THE FORMULATION STRATEGY
Select the right formulation, such as solution, emulsion, or oil, based on the solubility approach, excipient compatibility, and sensory profile.
PRESERVATIVE STRATEGY
Develop a preservative strategy and supporting studies, including preservative efficacy testing when applicable.
CONFIRM PACKAGING AND DEVICE FIT
Align packaging components with formulation properties to support consistent dose delivery and practical use.
STANDARDIZE GMP EXECUTION
Establish a reproducible manufacturing process with in-house analytical support and an ICH-aligned stability plan.
Our Capabilities
We support liquid products with capabilities built around stable performance, reliable dose delivery, and scale-ready execution.
Oral Liquids
Support flexible dosing and patient-friendly administration through solutions and emulsions designed for stable performance, practical use, and real-world application.
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Co-solvents, pH adjustment, or complexation aligned to the API and target profile.
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Sweeteners, flavor systems, and bitter blockers when relevant to the product.
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Preservative systems selected to support microbiological control and product acceptability.
Nasal Liquids
Stable formulation performance and consistent delivery are achieved by aligning formulation, preservation strategy, and device fit to support reliable use.
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Formulation mucoadhesion adjusted to support mucosal retention and user comfort, where applicable.
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Approach designed to support uniform delivery across packaging design.
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Metered-dose or non-metered packaging selected to match formulation and packaging design.
Sublingual Liquids
Sublingual liquids require controlled delivery and packaging that supports consistent use. We align formulation with device compatibility to ensure reliable dosing and administration.
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Pump or spray systems aligned to formulation properties and dosing goals.
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Formulation and process choices focused on sensorial feel and uniform delivery across actuations.
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Preservative excipient and testing approach aligned to non-sterile requirements, including PET when applicable.
Otic Liquids
Require stable formulation performance and consistent delivery through the chosen presentation. We align formulation, preservation strategy, and device fit to support reliable use.
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Robust preservative selection and microbial control aligned to non-sterile otic use, including PET when applicable.
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Dropper or pump selection aligned to consistent dosing expectations.
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Excipients and formulation choices tuned to support comfortable, practical use.
Topical Liquids
Dermatologic and mucosal applications require spreadability and cosmetic acceptability. We balance performance and usability through formulation aligned with the application.
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Excipient selection aligned to absorption goals and skin compatibility.
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Alcohol-free and non-irritant systems developed when appropriate for sensitive sites.
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Residue, drying time, and stability assessed under expected usage conditions.
Oil-Based Liquids
Lipophilic APIs are well-suited to oil-based systems that support the delivery profile. We optimize oil selection and packaging to ensure stable performance and practical dosing.
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Dropper bottles or soft tubes selected to support practical, controlled dosing.
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Preservation approach aligned to the system’s composition and intended use.
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Mineral and vegetable oil, medium-chain triglycerides, or ester-based blends selected to support stability and API compatibility.
Our Services
We align development, analytics, and GMP execution for liquid drug products to ensure stability, microbiological control, and reliable dosing.
Product Development
Manufacturing-ready liquid formulations, built for stability and reliable dose delivery.
Analytical Services
Fit-for-purpose testing to support stability, preservation, and confident release.
Manufacturing & Packaging
GMP execution and presentation fit aligned to consistent dosing through droppers, pumps, or sprays.
We make liquid performance predictable by aligning stability, preservation, and presentation fit from the start.
Resources
Explore content that helps plan non-sterile liquid drug products with clarity, from formulation strategy to scale-up execution.