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March 23-26, 2026
New York City
Scalable processes by design
We use QbD from the start to define CQAs, identify CPPs affecting viscosity, uniformity, and API release, and build a scalable process supported by the right documentation.
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Formulation Robustness
We run product compatibility studies to reduce the impact of the formulation and packaging components. We also support leachable and extractable studies.
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Critical Quality Attributes
Translate target product profile into CQAs that matter most for semi-solids, such as consistency, uniformity, stability, and performance-relevant characteristics.
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Critical Process Parameters
Identify process parameters that influence viscosity behavior, uniformity, and API release, with specific attention to mixing and filling conditions.
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Consistency across the lifecycle
Apply control strategy to maintain consistent semi‑solid process and product performance throughout the lifecycle and support process validation and routine production.
Establish a scalable process
We define a reproducible process suitable for clinical, exhibit, and commercial production, supported by fit-for-purpose analytical methods aligned with semi-solid scale-up.
Dosage Form capabilities
Groupe PARIMA applies dosage-form-specific development and manufacturing capabilities to keep critical attributes consistent as scale-up, equipment, and demand evolve.
Cream
We develop oil-in-water and water-in-oil creams using high-shear homogenization, validated for viscosity, droplet size, and phase stability across shelf life.
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Emulsion stability under temperature cycling.
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Homogeneous distribution of poorly soluble APIs.
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Optimization of pH and preservative systems for microbial protection.
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Ointment
We develop ointments with controlled API solubilization or dispersion and consistent texture and in vitro permeation testing as needed.
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Choose the right oleaginous or absorption base.
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Resolve issues with API sedimentation or crystallization.
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Minimize grittiness and ensure consistent texture and application profile.
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Lotion
We develop lotions with controlled flow properties and stable emulsions, using a scale-ready approach that maintains uniformity through optimized mixing, shear, and cooling profiles.
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Enhance spreadability without compromising API stability.
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Select non-irritant emulsifiers and humectants for sensitive applications.
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Ensure physical stability and microbial robustness in low-viscosity systems.
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Gel
We develop gels with highly sensitive to formulation conditions such as polymer level and pH, which is why control matters early. Our team applies IVRT to support formulation optimization and strengthen decision-making.
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Select gelling agents based on viscosity and drug release.
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Resolve API-polymer interactions that may impact clarity or stability.
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Ensure batch-to-batch rheological consistency using detailed viscosity and texture analysis.
Our Services
We connect development, analytical support, and GMP execution to manage semi-solid variables proactively and keep timelines moving.
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Product Development
Formulate and optimize semi-solids with tight control of texture, uniformity, and stability.
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Analytical Services
Use fit-for-purpose testing to confirm consistency, performance, and stability as you scale-up.
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Manufacturing & Packaging
Manufacture and fill semi-solids reliably by controlling mixing, temperature, shear, and filling conditions.